weather
reading the reports, I'd say wed is your day. 2-4 mainly in a s swell, winds around 5 kts.
TBS I wouldn't recommend going to the butterfish hole in a 22 footer. I used to run a 26 and my log book shows many an entry that says I need a bigger boat just running in from that area.
The other problem you might experience is that you're looking for really unique weather conditions since you really want a breeze of 10+knots to ensure a quality drift, but those winds will create less than ideal travelling conditions for you.
One more thing if you're getting "out there" add in a life raft to your safety equipment even if it's a coastal version. I certainly feel alot safer with one on board, especially when we're talking shark fishing.
Since you're from Southold, you can certainly run to the point and around and see whether the seas are too much, you can always just fish the point or Gardiners, even Block I to make the trip worth while.
One other thing I could offer is that there are plenty of sharks within a few miles of the beach, people just don't normally set up there to fish for them. You may want to just get around the point and set up 8-10 miles out, drop in some chum, they are there, plus you can fluke all day and put some meat in the box.
Just a suggestion, good luck and be safe!