Flouro is great for leaders, but it is expensive, and I really don't find that it is necessary with fluke. They don't seem to be very line shy. I'll use a circle or a wide gap hook on a 24" 20 pound clear Andy leader and all I use for bait is a shiner hooked through the eyes. No squid, spinners, or bucktail. I like to make the bait look as natural as possible and the fish seem to like it too. I will also use a bucktail teaser, green with pearl flashabou, tied about 18" up the line and put another shiner on that hook. This will pick up fluke, stripers, blues, and seabass.
I will often fish a bait rod and jig with a silver bullet also tipped with a spearing instead of squid. Gamakatsu's method of using one instead of a sinker is an interesting technique I think I will try next year. Make your own decision, West Marine sells Seaguar Flouro for a pretty reasonable price.